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der Versuch, mit der Komplexität umzugehen
Die unglaubliche Fülle der Fakten werden hier in einer Art Kurzanleitung dargestellt. Haben Sie sich im Teil 1-3 von der Richtigkeit des Konzeptes überzeugt? Wenn ja, dann finden Sie hier die passenden Rezepte für den Umgang mit dem Vitamin-D-Mangel.

Vitamin D hilft gegen Brustkrebs - in 3 Dimensionen

Topaktuelle Informationen

über den Einsatz von Vitamin D bei Brustkrebs

als leicht verständliche Poster im Powerpoint-Stil:

 

Der Inhalt:

  • Der gesamte Vortrag hat 261 Poster:
  • davon 55 verständliche Fragen und 55 verständliche Antworten
  • fachlich fundierte Inhalte auf 151 farbigen Darstellungen
  • für ein Verstehen durch Sehen.

Wissenschaftliche Fakten, die dank Vitamin D die gesamte Krebstherapie revolutionieren werden.

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Das Inhaltsverzeichnis:

Vitamin D hilft gegen Brustkrebs –
in drei Dimensionen

VitaminD-Hilfe-Brustkrebs VitaminD-Hilfe-Brustkrebs

Dr. med. Raimund von Helden,
Facharzt für Allgemeinmedizin,
Institut VitaminDelta.de, Lennestadt


VitaminD-Hilfe-Brustkrebs VitaminD-Hilfe-Brustkrebs

 

Was ist „ganzheitliche Medizin“?

 

Kapitel 1: es betrifft uns alle…

Was ist das Besondere an Vitamin D ?

Was ist das heilsame Prinzip einer Erholungskur ?

Wie ist der Kureffekt im Herbst und Winter?

Wann war ihre letzte Kur?

Wieso werden wir krank?

Wie ist die Studienlage beim Vitamin D?

Was geschieht, wenn Sonnenlicht fehlt ?

Gibt es einen Zusammenhang von Vitamin D und Brustkrebs?

Brustdrüse: was geschieht, wenn Vitamin D fehlt?

Wieso ist Vitamin D so mächtig?

Welches Hormon fand man der Entdeckung des Vitamin D als nächstes?

Was ist die Arbeitsweiseeines Hormons?

Welche Rolle spielt der Vitamin-D-Rezeptor bei Brustkrebs ?

Wann entstand das Vitamin D-Schutzsystem unserer Erbanlagen?

Warum erzeugen alle Lebewesen Vitamin D?

Wie ist der globale Rang des Vitamin D ?

 

Kapitel 2: die Quellen…

Wer steht hinter diesem Wissen über Vitamin D?

 

Kapitel 3: die Ergebnisse…

Kann uns Sonne vor Krebs schützen?

Wieso haben wir trotz Sonnenlicht ein Vitamin-D-Problem?

Wird Brustkrebs durch Sonne verhindert?

Kann man den Mangel an Vitamin D bei Brustkrebs nachweisen?

Ist Sonnenschein stets mit der Abwehr von Krebs verknüpft ?

Was bedeutet der Vitamin-D-Schutz für meinen  Lebensstil?

Verbessert normales Vitamin D die Chemotherapie ?

Was sagt die Stanford University über Brustkrebs und Vitamin D?

Was nützt Vitamin D im Verlauf der Krankheit?

Was nützt Vitamin D bei verschiedenen Arten von Brustkrebs?

Wie lautet das Gesamturteil über das Vitamin D in der Krebstherapie?

Was bedeutet: „Vitamin D hilft in 3 Dimensionen“ ?

 

Kapitel 4…Umsetzung

Welcher Vitamin-D-Wert ist normal?

Warum sind unsere Vitamin-D-Werte so schlecht?

Welche Nahrung hilft uns weiter?

Was sagen die Experten dazu?

Wie kann ich an Vitamin D gelangen?

Wie gut sind Brustkrebs-Patienten mit Vitamin D versorgt?

Wie komme ich an einen schützenden Vitamin-D-Spiegel?

Wie viel Vitamin D benötige ich?

Welche Folgen hat die Korrektur des Vitamin D-Wertes?

Wo wirkt sich der verbesserte Vitamin D-Spiegel aus?

Wie erreicht man einen anhaltend hohen Vitamin-D-Wert?

Wie groß ist die Streuung wenn man keine Formel verwendet?

Ist die Therapie mit Vitamin D neu?

Wieso schützt Sport vor Krebs?

Welche Rolle spielt eine vegetarische Ernährung?

Wie viel Minuten Mittagssonne brauche ich?

Welche Rolle spielt die Bekleidung?

Löst Sonne denn nicht Hautkrebs aus?

Warum wird vor Hautschäden durch Sonne gewarnt?

Was ist von den Warnungen vor Hautkrebs zu halten?

Aber es gibt doch tödlichen Hautkrebs?

Was ist von Sonnencreme zu halten?

Wo ist der Beweis für gefahrlose Minuten in der Sonne?

Welche Krebs- Risiken habe ich mit und ohne Sonne?

Seit wann gibt es dieses Wissen über den Nutzen des Sonnenlichtes?

 

Anhang:

Was ist mit „VitaminDelta“ gemeint?

Kurzbericht: Projekt VitaminDelta – was ist das?

Danksagung

 

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VitaminD-Ebook-gegen-Krebs

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Wirkmechanismus

Kann der Wirkmechanismus des Vitamin D-Systems die Erfolge erklären?

Vitamin D ist die Tür zu einem Hormonsystem. Die Grafik zeigt, was Vitamine sind und

 

Kindesmisshandlung

Kindesmisshandlung oder Vitamin-D-Mangel ("Rachitis")?

mit freundlicher Genehmigung übernommen von: www.VitaminDCouncil.org

Ein Dankeschön an John Cannell !

Vorwort:

Die fehlende Wahrnehmung des landesweiten Mangels an Vitamin D durch viele Ärzte hat dazu geführt, dass immer wieder von Kindesmisshandlung gesprochen wird, wo die korrekte Diagnose eigentlich lauten müßte: Vitamin-D-Mangel mit Spontanfrakturen. Nicht die Eltern sind in diesem Fall für diese Verletzungen verantwortlich, sondern eine fehlerhafte Gesundheitspolitik der zuständigen Institutionen.

Dr. med. Raimund von Helden

Den englischen Artikel können Sie durch die automatische Übersetzungsfunktion von Google übersetzen lassen.


Child Abuse? Or Vitamin D Deficiency Rickets?

"By the streams of Babylon we sat down and wept when we remembered Zion." (Psalms 137:1)

Dr. Cannell: I am writing to ask your help because I think my problem has something to do with Vitamin D. Six months ago, Marissa, who is now one-year-old, developed a painless bump on her arm. I watch her closely; I know she did not fall; she was only six months at the time. In the emergency room they found a broken bone in her arm and then x-rayed her entire body and found two more broken bones, but these other two places were not swollen and Marissa did not cry when the doctor pushed on the area.

Well, a child abuse expert was called in and we were accused of abuse and they took our baby away, saying we had beaten her. I can't forget Marissa screaming when they tore her out of my arms. We were shocked. We could never do such a thing. Even though they could not find any evidence of abuse except these broken bones, the DA tells me if I don't plead guilty and testify against my husband and say he did it, I will be prosecuted as well and never see my baby again. Our lawyer says I can be forced to testify against my husband in child abuse but he would never hurt Marissa. I don't know what to do. My husband is ready to plead guilty to save our baby from foster care but I don't think I can let him do that.

I have learned of other African American parents in the same situation. Neither of us would ever abuse our child, it took seven years of trying and then infertility treatment to have her. The reason I am writing is because I have read about cases of rickets where unexplained fractures are common, especially in African Americans like us, that are being called child abuse. I breast fed Marissa but I now know that breast milk doesn't have enough Vitamin D. We should have given it to her but our pediatrician never said anything about it and La Leche league says breast milk is all infants need.

When we learned Vitamin D may be involved, I asked my doctor to test me and my level was 5 at first. He prescribed Drisdol and now it is 18 after taking 50,000 IU per week for two months. When our lawyer brought up rickets and Vitamin D deficiency the DA had Marissa x-rayed for rickets and tested for Vitamin D; her x-rays were normal and her blood level is now 21, but the child abuse doctors never tested her for Vitamin D when they first took her away from us and she had been on 400 IU formula in foster care for five months when they finally tested her.

We had another radiologist look at the original x-rays and compare them to her current ones. He said it looked like rickets and he said her bones look much better now at the growth areas. However, when he found out it was a child abuse case he said he would not get involved.

From your website, I learned breast-feeding mothers have to take 6,000 IU a day to get enough Vitamin D in breast milk. Marissa never went in the sun; our pediatrician said babies should never go in the sun. I don't know what to do. I know you used to testify in child abuse cases, will you help us? We can pay. Kathryn, Boston, MA

The American Legal System and Child Abuse Allegations

No, I won't testify. The American legal system, when it comes to child abuse allegations, is no Zion. My years testifying in child abuse allegations involved the "memory wars," and those wars are over, won by plaintiff attorneys suing psychiatrists, often with the help of my testimony. However, I will put you in touch with a pediatric radiologist who may be able to help.

My interest in child abuse cases started with the McMartin preschool case. (I immediately thought the McMartins and Buckeys all totally innocent as I recognized the most fatal of the psychiatric disorders, hysteria, in those prosecuting them. I still remember Ray Buckey looking into the camera, with panic-stricken media all around him, saying, "This could happen to you.") My involvement in such cases ended with the Archdiocese of Boston case. (I thought the priest I was hired to defend guilty.)

My cases centered on recovered memory therapy, especially multiple personality disorder (MPD), a now discarded and discredited psychiatric diagnosis that destroyed thousands of innocent American families. Of note, during my 15 years of work in the field, every MPD patient I saw had excellent mental health insurance coverage. That is, the absence of mental health insurance apparently protects one from contracting multiple personality disorder.

Vitamin D Deficiency Commonly Misdiagnosed As Physical Child Abuse

The issues you raise about Vitamin D deficiency being misdiagnosed as child physical abuse are so common they were recently the topic of four papers in Pediatric Radiology. First, Drs. Kathy Keller and Patrick Barnes, both pediatric radiologists, published four cases reports. The course of each child was similar. Concerned parents took their child to the doctor for leg bumps, well baby checks, or even the flu. X-rays showed multiple skeletal fractures that were asymptomatic. No mention of bruises, skin abrasions, retinal hemorrhages, parental drug abuse, parental sociopathy, nor evidence the child was frightened of their parents. The children had been seen previously by physicians, nurses, lactation consultants, day-care workers, audiologists, family and friends with no suspicions of abuse. Such parents often have a reputation of being the most protective and concerned parents on the block. Drs. Keller and Barnes thought all four children had rickets.

The key here is the history as much as x-rays. These are often black children, living above latitude 35 degrees, usually breastfeeding without Vitamin D supplementation, often born in the late winter or early spring. The key on exam is that the fractures are painless, unlike traumatic fractures, and there are no bruises. A common finding in the neonatal medical record is craniotabes, or softening of the skull. About 20% of "normal" newborns have soft bones as evidence by craniotabes; of course these newborns are not normal, they are simply the newest additions to the Vitamin D deficiency pandemic.

Newborn vitamin D levels not routinely measured

Unfortunately, as 25(OH)D levels are not routinely measured on American newborns, we do not recognize the multitude of afflicted infants, and the infants seldom get Vitamin D, unless they are on formula. Even if they are on formula, 12 months later they are weaned on the empty calories of "natural fruit juice," instead of "evil cow's milk," so the deficiency is just delayed by the Vitamin D formula, not prevented. That is why so many cases of autism present around 12–18 months; it is not the presence of vaccinations but the disappearance of Vitamin D; the two just happen to co-occur.

The sun-scare of the American Academy of Pediatrics

Kathryn, as far as your pediatrician telling you babies should never go in the sun, he is just following the guidelines of the American Academy of Pediatrics (AAP). In 1999, the AAP advised mothers to always keep infants out of direct sunlight, use sun-protective clothes and sunblock, and make sure children's activities in general minimize sunlight exposure. Furthermore, quite inexplicably, the AAP scientists claimed there was "no evidence" such an unprecedented and radical bit of advice would affect vitamin D levels (p. 330).

"Third Wave" of Rickets Currently Underway

Getting back to the papers in Pediatric Radiology, Professor Russell Chesney, Chairman of the University of Tennessee Health Science Center Department of Pediatrics, went next, warning readers we are currently in the "third wave" of rickets; the first caused by air pollution during the industrial revolution, the second wave occurred during the 1980s mainly due to La Leche League-type breast-feeding among heavily clothed immigrants, and the current third wave. (The current wave of rickets is the gift of the sun-scare academic dermatologists, who, in turn, are gifted multi-million dollar grants from the cosmetic and sun-screen industry.) Professor Chesney points out that asymptomatic fracture from Vitamin D deficiency is not uncommon, adding that similar fractures have been noted in young arctic foxes, alpacas, and polar bears kept in zoos, all who apparently suffer such fractures during normal play—unless arctic foxes abuse their kids. I suspect arctic fox infants will get adequate Vitamin D long before African American infants.

Authorities fail to see, or acknowledge, the connection

Next, Dr. Carole Jenny, head of the American Academy of Pediatrics Section on Child Abuse, implies such tragic miscarriages of justice simply don't happen. She then claims, "We have been checking every child with multiple fractures for metabolic bone diseases for several years and have not identified a single child with Vitamin D deficiency." How can that statement be true if every other researcher is reporting infantile and early childhood Vitamin D deficiency to be rampant in normal children? Furthermore, how can an infant beaten severely enough to cause multiple fractures not be bruised or in distress? Dr. Jenny cleverly avoids the question.

Finally, we have commentary by two additional pediatric radiologists, Drs. Thomas Slovis and Stephen Chapman, who make it clear they do not believe in the Vitamin D deficiency pandemic. They found an illustrated medical dictionary to support their claim that one cannot have rickets unless one has x-ray evidence of rickets. If they had found a dictionary with more words and fewer pictures they would discover rickets is defined pathologically, not radiologically.

In fact, in the largest cases series of rickets in Canada, Dr. Leanne Ward and her colleagues at the University of Ottawa found 7% of the rachitic children did not have evidence of rickets on their x-rays, the diagnosis was made by low 25(OH)D levels (mean in the 104 cases was 6 ng/mL) and by elevated alkaline phosphatase levels (mean 1237 U/L). So Canadian physicians wisely feel they can diagnose rickets even when x-rays are "normal."

However, Drs. Slovis and Chapman correctly point out how subjective the diagnosis of bone demineralization is on plain film x-rays. Then, they go on to dispute the rickets diagnosis made by Drs. Keller and Barnes in the four case reports, proving the x-ray diagnosis of rickets is also subjective—at least in these four cases, as two pediatric radiologists diagnosed rickets and two did not, looking at the same four sets of x-rays in four separate cases!

Kathryn, like your baby, the 25(OH)D levels in these cases were not taken at the time abuse was alleged, but apparently months later after the baby had been on Vitamin D formula. However, the mothers, like you, who were apparently breast feeding their baby without Vitamin D supplementation, had low 25(OH)D levels; one was 4 ng/mL and another 8 ng/mL.

Microscopic bone abnormalities

A remarkable Australian paper is in press, looking at bone specimens and blood samples from people killed in accidents. (Apparently, ladies, some of the men staring at you are not admiring your figure, but are waiting for you to get run over by a car so they can take your blood and x-ray you.) These researchers found that unless one has 25(OH)D levels above 36 ng/mL, one has microscopic bony abnormalities. Thus, perhaps as many as 50% of American children have microscopic bone abnormalities that radiologists cannot see, as >50% of American children have levels below 36 ng/mL. Drs. Slovis and Chapman, like many radiologists, have been looking at abnormal x-rays of children's bones so long they don't know what normal is.

Subclinical rickets a "normal variant"

However, Drs. Slovis and Chapman have discovered something without knowing it. They point out that rachitic changes in the elbow are a "normal variant." I'll bet you the house that this "normal variant," like craniotabes, is present much more often in severely Vitamin D-deficient children. That is, subclinical rickets is so common it is routinely missed by radiologists because its first radiological signs are in the ulna and those rachitic changes are interpreted as a "normal variant."

Fractures common in rickets

As far as fractures in rickets, they are not uncommon. In fact, I could not find a large case series of rickets without some of the children having fractures. One case series from the University of Pennsylvania Medical School in 1979 found about 20% of the rachitic children had fractures. I like this case series as it may contain the first case report of an autistic child being cured with Vitamin D.

Autism, Rickets, and Vitamin D

The paper reports a rachitic, 16-month-old child who was breast-fed without maternal or child Vitamin D supplementation, presented with generalized demineralization, a fractured tibia, and severe rickets. Her parents were Muslim and both mother and child wore black robes, indoors and out. After weaning, the child's diet consisted entirely of fruits, vegetables, and grains. Her early development was normal; she began talking at age 13 months, but lost all her speech at 15 months. On exam she was hypotonic, she did not speak during her 6-day hospital stay, and her developmental milestones were delayed. No psychiatric exam was done as autism was exceptionally rare in 1979; the authors did not comment on her social interactions. She was treated with 100,000 IU Vitamin D as a single Stoss dose, and then 2,000 IU per day. She was lost to follow up for 18 months but continued the 2,000 IU per day. When seen, her hypotonia had disappeared (hypotonia is present in 50% of autistic children), her developmental milestones were normal, and her speech had returned. If an earlier case report of Vitamin D curing autism exists, I cannot locate it.

As a medical student at UNC I studied rickets one summer in Iran, long before Vitamin D testing was available. I was amazed at how "normal" appearing bones in children with greatly elevated alkaline phosphatase levels became so much more normal after 250,000 IU of Vitamin D a week for ten weeks. The Vitamin D dramatically lowered alkaline phosphatase (often into the normal adult range (20–140 U/L), indicating the "normal" alkaline phosphatase upper limit for children (500 U/L) is but another indication of pandemic childhood Vitamin D deficiency. I remember these children as shy, withdrawn loners but I never asked mothers about their child's speech. When I looked at the x-rays of the growth plates of the bones of autistic children recently published by Dr. Mary Hediger and colleagues at the NIH, I thought how much more normal those growth plates would look after Vitamin D treatment, and if their autism would improve.

"Beyond a Reasonable Doubt" Rule Does Not Apply

Kathryn, you, your husband, your child, and your family are in a world of trouble. Unlike murder, the "beyond a reasonable doubt" rule does not extend to child abuse allegations. I know that it is supposed to, but it seldom does and is one of the reasons I stopped testifying. Judges and juries treat child abuse allegations on the basis that "if there is smoke, then there is fire." Time and time again I have seen the most idiotic testimony be accepted by agape judges and naïve juries who are afraid they might let a child abuser go free. "Better jail ten innocents than let one child abuser go free," is their motto.

Three hundred and sixteen years ago, the Reverend Increase Mather, Cotton Mather's father, gave the opposite advice in Salem, Massachusetts. He paraphrased Blackstone when he said that it was better to let ten witches go free than to shed the blood of one innocent woman, and Reverend Increase Mather earnestly believed in witches. His and Blackstone's earlier advice (better that ten guilty go free than one innocent be convicted) does not apply to child abuse in 21st Century America. That said, we all know child abuse is all too real and witches are not. However, I dare anyone to look at the American Satanic Ritual Abuse cases of the 1980s and early 1990s and say that that was not witchcraft allegations under another name. Nor did that fact help any of the hundreds of innocents jailed during the day-care child abuse hysteria of the same era.

We have no way of knowing how many innocent African American families have been, and will be, destroyed when child abuse experts misdiagnose the fractures and pseudo-fractures (Looser's zones) of rickets as child abuse. In a recent report of two such cases, Dr. Senniappan of Saint Mary's Hospital in England gave some good advice that was ignored in your case: "Clinicians have the duty to exclude the possibility of an underlying medical disorder associated with skeletal fragility," and they have to do so at the time the diagnosis of child abuse is considered, not six months later after the child has been given Vitamin D and calcium in formula.

In Scotland, Dr. Colin Patterson of the Ninewells Hospital in Dundee reported on a case of unexplained fractures and warned, "A mistaken diagnosis of abuse can lead to irreparable damage to both family and child."

Kathryn, as far as the deal the DA is offering (having you plead guilty, dropping abuse charges against you, having your husband plead guilty and go to prison, and giving you your child back if you enter testimony against your husband), this is usually how the DA gets a conviction of "confirmed" child abuse. It is an unusual woman who would risk both prison and her child to defend the truth—not to mention a husband.

However, it happens.

Few people know that all of the 20 people hung in Salem 316 years ago denied they were witches. (As Dr. Jenny would say, they were "in denial.") Not one confessed witch was hung (they were jailed instead and eventually freed) and many confessed to being witches. That is, the Salem DA offered accused witches the same deal you are getting: confess and I won't destroy you. Twenty brave souls in Salem Massachusetts chose death over a lie.

John Jacob Cannell MD Executive Director

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Vitamin D and the VDR - how we discovered it

On the History of Vitamin D Targets:

Their Discoveries, Localization and Related Functions


Walter E. Stumpf – University of North Carolina, Chapel Hill
(www.walterstumpf.com)
 

With the histochemical approach of high resolution receptor microscopic autoradiography, we discovered target cells in the brain, spinal cord, pituitary, thymus and skin in 1979 (Science), and elsewhere during the 1980s and early 1990s. Over 50 identified target tissues were reviewed in 1995 (Stumpf WE, Histochem. Cell Biol. 104, 417-427), most of them unrelated to systemic calcium regulation.[1] This was in contrast to the five “classical targets” of bone, intestine, kidney, liver, and parathyroid, under the Procrustian calcium concept that stifled vitamin D research.  

 

A new paradigm evolved: Vitamin D is primarily about the adaptation of vital functions to the seasonal solar environment, a primary biological role that is broader than mere calcium regulation (Stumpf WE, 2007. Europ. J. Drug Metab. Pharmacokin. 32, 1-6). In addition to bone growth and repair, effects on other vital functions (such as cell proliferation, differentiation, secretion) are equally or more important, depending on the situation.  These other functions are not as easily monitored as bone conditions, but indicated by the strong nuclear receptor binding of 3H-1,25(OH)2 vitamin D3 on an array of targets that include:

·         skin epidermis, hair follicles, sebaceous and sweat glands; myoepithelial cells;

·         certain brain and spinal cord neurons;

·         specific cells in anterior (esp. thyrotropes) and posterior pituitary;

·         thymus reticular cells; adrenal medullary cells;

·         stomach gland isthmus cells, entero-endocrine cells, and pyloric muscle cells;

·         pancreas beta cells;

·         heart atrial myocytes;

·         special cells in salivary glands;

·         cell population in female and male reproductive organs[2].

In the liver, there is accumulation and retention of radiolabel in cytoplasm of sinus littoral cells, probably Ito cells. These cells, known to store vitamin A, apparently are also storing 1,25(OH)2 vitamin D3 as well as 25(OH) vitamin D3  (Stumpf WE, 2008. Eur. J. Drug Metab. Pharmacokinet.3, 85-100). We did not, however, find evidence for receptor binding of either 24,25(OH)2 vitamin D3 and 25(OH) vitamin D3 or of specific plasma membrane associations with 1,25(OH)2 vitamin D3, contrary to claims by some biochemical reports..[3]  Furthermore, no nuclear uptake of vitamin D was seen in mammalian skeletal muscle cells, and no evidence for storage of vitamin D in fat cells, both also occasionally claimed in biochemical reports. However, we noted uptake and retention in the ground substance of mucosae, probably a secondary storage site in addition to plasma protein.
 

Target-related structures and functions were characterized through combined autoradiography- immunocytochemistry with antibodies to receptor or secretory products. Biochemical and clinical follow-up confirmed and extended these findings. A number of vitamin D target cell populations have not yet received attention. These include pyloric muscle, stomach isthmus
neck cells, hair sheath keratinocytes, testis Sertoli cells, epididymis epithelial cells, certain brain, spinal cord, and spinal ganglion target cells, placenta, oviduct fimbriae, ovarian germinal epithelial cells, and others – the list is too long to discuss here.
Considering the current status of vitamin D targets and related functions, it is evident that histochemical discoveries preceded recent developments by 20 to 30 years. Vitamin D research is now at a stage similar to that of estradiol research during the 1960s. Back then, both biochemistry and histochemistry interacted fruitfully at the University of Chicago. Soon it became apparent that target tissues of estradiol, “the hormone of reproduction,” are not
limited to reproductive organs. Instead they exist throughout the body at specific sites, as is now also accepted for vitamin D.  Much of the increased vitamin D appreciation in recent years can also be credited to improved blood assays of vitamin D metabolites and the related revision of salubrious dosing of 25(0H) vitamin D3. But the full recognition of vitamin D targets and actions is still to come.


While the complete significance of Vitamin D is yet to be revealed, it is clear that both scientific methods and the related mindset of the scientific community underlie our changing understanding of nature.

 

 



[1]At the time, non-calcitropic targets were ignored or downgraded (a typical Ca-expert comment: “These are a few cells, it does not matter.”). A few biochemists followed up with pituitary and skin cell lines, providing supportive data, without acknowledging the original discovery. Such omissions are not uncommon in science (Kuhn, T.S., 1962.The structure of scientific revolutions).

[2]Is Vitamin D another “hormone of reproduction,” like estradiol?  See later discussion of estradiol.

[3]Such negative findings do not exclude possible actions under certain conditions, which points to the merits of further study.

 


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